Dilantin SJS and TEN There is a potential increased risk of serious skin reactions including Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from phenytoin therapy. Epileptic patients taking dilantin to control seizures should be aware of these health risks.

Stevens Johnson Syndrome (SJS)

Stevens Johnson Syndrome is a rare and serious disease that affects the mucous membranes and the skin, eventually resulting in the epidermis (the outer layers of skin) separating from the dermis (inner layers of skin). SJS is closely related to TENS (Toxic Epidermal Necrolysis), which affects the skin in the same way but can lead to the separation of one hundred percent of the epidermis. SJS is said to be a milder form of TENS, affecting up to thirty percent or more of the epidermis. SJS has been linked to many prescription medications and a multitude of common over-the-counter treatments as well. Stevens Johnson Syndrome is similar to Lyell's Syndrome.

Dilantin Toxic Epidermal Necrolysis (TEN)

Toxic Epidermal Necrolysis (TEN), also known as Lyell's Syndrome, is said to be a more severe form of Stevens Johnson Syndrome with mortality and morbidity rates that are much higher than SJS. Like SJS, TENS & Lyell's Syndrome are a immune complex-mediated hypersensitivity complex that is a severe expression of erythema multiforme and involves the skin and mucous membranes. Again, as with SJS, there is significant involvement of oral, nasal, eye, vaginal, urethral, GI, and lower respiratory tract mucous membranes in Toxic Epidermal Necrolysis (TEN).

In the case of the oral, nasal, and ocular membranes, it is likely that the mucosal pseudomembrane formation may lead to mucosal scarring and loss of function of the involved organ system, leaving the patient blind and unable to breathe, eat, or speak on their own.

Speak to a Lawyer

If you or your child has suffered Stevens Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) from taking dilantin, contact an attorney at our law firm to discuss your legal options.

Please fill out our free legal evaluation form on the far right and we will call or e-mail you back within 24 hours. Please keep in mind that certain states have a statute of limitations that limits the amount of time you have to file a lawsuit or seek legal action. Contact our law firm immediately so we may explain the rights and options available to you and your family.